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October 3, 2024eLifeOpen Access

Novel risk loci for COVID-19 hospitalization among admixed American populations

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Authors

SASilvia Diz‐de AlmeidaUniversidade de Santiago de CompostelaRCRaquel CruzCenter for Research in Molecular Medicine and Chronic DiseasesALAndré Ducati LuchessiUniversidade Federal do Rio Grande

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Overview

Genome-wide association study identifies novel risk loci for COVID-19 hospitalization in admixed American populations, highlighting the critical value of diverse ancestral cohorts.

Key Points

  • Analysis reveals four genome-wide significant risk loci for COVID-19 hospitalization, including novel associations at BAZ2B and DDIAS first identified in Latin American cohorts.
  • Genome-wide association study evaluated 4,702 hospitalized cases across multiple cohorts, and trans-ethnic meta-analysis uncovered an additional cross-population locus in CREBBP.
  • Evaluation of a cross-ancestry polygenic risk score highlights the transferability of genetic predictors and emphasizes the necessity of diverse ancestries in genomic medicine.

Cite This Study

Almeida et al. (2024) studied this question.

synapsesocial.com/papers/68e55ee7e2b3180350efbce5https://doi.org/10.7554/elife.93666.3
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