October 2, 2024Kazan medical journalOpen Access

Possibilities of using secondary plant metabolites as antitumor agents

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Authors

EZE. Yu. ZlatnikMinistry of Health of the Russian Federation ASA. B. SagakyantsSouthern Federal University ENE. M. NepomnyashchayaMinistry of Health of the Russian Federation

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Implication

Review reveals antitumor and immunomodulatory actions of secondary plant metabolites in tumor models, highlighting the need for novel delivery systems to overcome low bioavailability.

Key Points

Secondary plant metabolites exhibit antitumor effects by regulating transcription factors, signaling pathways, and cellular receptors controlling proliferation and apoptosis.
Literature review across PubMed and eLibrary databases evaluated the pleiotropic actions of berberine, curcumin, and related derivatives on cellular targets and immune response.
Highlights that low bioavailability and contradictory clinical trial outcomes restrict current oncology applications, underscoring the necessity for modern chemical delivery systems.

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Zlatnik et al. (2024) studied this question.

synapsesocial.com/papers/68e55ef6e2b3180350efc4bf https://doi.org/10.17816/kmj634368

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Implication

Review reveals antitumor and immunomodulatory actions of secondary plant metabolites in tumor models, highlighting the need for novel delivery systems to overcome low bioavailability.

Possibilities of using secondary plant metabolites as antitumor agents

Discussion

Member takes

Implication

Key Points

Cite This Study

Possibilities of using secondary plant metabolites as antitumor agents

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider