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October 1, 2024Ecotoxicology and Environmental SafetyOpen Access

Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease

Xuena Yang Huan Liu Shiqiang Cheng Chuyu Pan Qingqing Cai Xiaoge Chu Sirong Shi Wenming Wei Dan He Bolun Cheng Yan Wen Yumeng Jia Alexey A. Tinkov Anatoly V. Skalny Feng Zhang

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Abstract

Kashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by excessive chondrocytes apoptosis. T-2 toxin exposure has been proved to be its etiology. Connective tissue growth factor (CTGF) exerts a profound influence on cartilage growth and metabolism. We investigated the potential role of CTGF in KBD development and examined CTGF alterations under T-2 toxin stimulation.

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Cite This Study

Yang et al. (2024) studied this question.

synapsesocial.com/papers/68e56113e2b3180350efdb06 https://doi.org/10.1016/j.ecoenv.2024.117148

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