7142 Herbal Supplements Cause Cushing's Syndrome

Abstract Disclosure: L. Del Carpio-Orantes: None. A. Aguilar-Silva: None. Á. Munguía-Sereno: None. A. Salas-González: None. K. González-Medel: None. K. González-Medel: None. J. Sánchez.Díaz: None. S. García-Méndez: None. R. Salazar-Lizárraga: None. R. Domínguez-Cámara: None. B. Rodriguez-Bonachea: None. V. Fonseca-Pouchoulen: None. Introduction: There are various supposedly herbal supplements that contain unreported doses of steroids and that cause Cushing's syndrome in their users, who most often suffer from various rheumatisms and chronic pain. There are international alerts on the consumption of these products by the FDAMaterial and methodsWe report a series of cases of patients affected by iatrogenic Cushing's syndrome due to consumption of apparently herbal products, in whom serum cortisol and ACTH and 24-hour urinary cortisol were measured.Results8 cases of iatrogenic Cushing's syndrome are reported, 75% women, average age 65 years, 75% suffered from osteoarthrosis and 25% rheumatoid arthritis, all consumed herbal supplements to relieve chronic pain, highlighting the intake of Artri king in 5 patients, Ortiga Ajo Rey in 2 patients and Artribion in 1 patient. Disruption of the hypothalamic-pituitary-adrenal axis was demonstrated in all of them, through the analysis of serum cortisol and ACTH and in some patients of 24-hour urinary cortisol. Unfortunately, 1 patient died from advanced Cushing's syndrome.ConclusionsThe consumption of these pseudoherbal products produces serious consequences for the health of the population, which is why regulatory authorities must put more emphasis on their control, being an international public health problem. Presentation: 6/3/2024