Supplementary Figure S1 from The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

Supplementary Figure S1 details the genetic vulnerabilities and modifiers of response associated with combination treatment of MRTX0902 with adagrasib in the KRAS G12C-mutant MIA PaCa-2 (S1A, S1B, S1D, and S1E) and LU99 (S1C) cell lines in vitro and in vivo.