Supplementary Figure S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

Supplemental Figure 3. Number of NMF components versus AUC. Performance (AUC) of NMF models in OVO comparisons is plotted against the number n components (Methods) used. The number of components approaches the AUC’s asymptote in each OVO at or before 20 components. Optimal number of components for each OVO was defined as the number of components yielding the highest AUC. AUC, area under the curve; OVO, one-versus-one comparison; NMF, non-negative matrix factorization.