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Abstract Background Anti-Mullerian hormone (AMH) is produced by follicles in women, and its measurement in blood may be a reliable indicator of ovarian reserve and ovarian function. It can also be of clinical value in the treatment of infertility. Many immunoassays gave been devolved to measure AMH in the blood. Recently a new AMH assay was developed by Snibe company with different immunoassay technique and detecting labeled. The aim of this study was to compare this new AMH immunoassay with the current under use immunoassays. Methods A total of 40 blood samples were collected from 40 Saudi women with age between 15 to 49 years. The samples were performed by both immunoassay Cobas e411 (Roche) and Maglumi 4000 plus (Snibe). The Cobas e411 uses Electrochemiluminescence immunoassay (ECLIA) with ruthenium(II) complex labeled, while Maglumi 4000 plus use Chemiluminescence immunoassay (CLIA) with different labeled ABEI. The measuring range was 0.071 to 164 pmol/L and 0.143 to 178 pmol/L for each assay respectively. The Microsoft Excel sheet was used and T Test was used to evaluate the comparison statistics with p value at (0.05). Results The correlation of coefficient was found to be 0.9418 between the two assays. The mean and standard deviation were calculated to be 11.8±13 pmol/L and 8.3±8.5 pmol/L for Cobas e411 and Maglumi 4000 plus respectively (p0.0001). Based on the reference interval for each assay, there was 100% agreement between the two assays. Conclusions The Anti-Mullerian Hormone assay by Maglumi 4000 plus (Snibe) had a very good correlation with current assay used in our laboratory and thus can be reliably used to measure AMH in the blood but as with current assay, interpretation of the result must be matched with other clinical findings.
Tamimi et al. (Tue,) studied this question.