September 30, 2024ChemMedChem

NIR Enhanced pH‐Responsive Microneedles for Synergetic Therapy of Melanoma

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Authors

WHWei‐Qiang HanIngenierie des Materiaux polymeres YLYu LanJinan University ZLZhuo LiuChinese Academy of Tropical Agricultural Sciences

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Implication

Preclinical study demonstrates synergetic chemo-photothermal immunotherapy via multifunctional microneedles in melanoma models, indicating enhanced tumor inhibition.

Key Points

Multifunctional microneedles trigger immunogenic cell death and inhibit melanoma growth, providing targeted drug release under near-infrared and acidic cues.
In vitro assessment of 3D tumor models demonstrates deep skin penetration guided by hyaluronic acid, delivering doxorubicin and curcumin directly to tumors.
Incorporation of polydopamine and 1-methyltryptophan enhances photothermal therapy and reverses immunosuppression—in vitro model; further in vivo work needed.

Cite This Study

Han et al. (2024) studied this question.

synapsesocial.com/papers/68e56395e2b3180350f007ff https://doi.org/10.1002/cmdc.202400537

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Implication

Preclinical study demonstrates synergetic chemo-photothermal immunotherapy via multifunctional microneedles in melanoma models, indicating enhanced tumor inhibition.

NIR Enhanced pH‐Responsive Microneedles for Synergetic Therapy of Melanoma

Discussion

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Implication

Key Points

Cite This Study

NIR Enhanced pH‐Responsive Microneedles for Synergetic Therapy of Melanoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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