Abstract In this paper we have reported synthesis evaluation imidazole by solvent free multi component scaffolds (NEAT Reaction) by simple and very effective protocol. The compounds were confirmed by ¹H NMR, Mass and I.R spectral studies. The theoretical interpretations of synthesized compounds with optimized by 6-311 + + G(d, p) basic set and different parameters using Gaussion-09 software .The PASS web-based application gave predicts the biological activity spectrum of a compound based on structure. It is useful to estimate the probable biological activity profile. The analysis shows that compound 6b shows high activity for Antieczematic and Gluconate 2-dehydrogenase (acceptor) inhibitor (Pa > 0.07). The bioactivity against Etiella zinkenella was evaluated. The result obtained showed a significant (P < 0.06) larvicidal activity with Lethal concentration (LC₅₀) = 0.22 ppm for compound 6d at concentration ranging between 0.02–0.08 ppm.
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Rayate et al. (2024) studied this question.
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