Design, Synthesis, and In-Silico Assessment of Imidazo2,1-bthiazol-5-amines for Promising Anti-Bacterial and Anti-Fungal Activity

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Novel imidazo[2,1-b]thiazole derivatives show promising antibacterial and antifungal activity against resistant pathogens.

Compounds 6a, 6b, and 6o showed significant antibacterial activity against P. aeruginosa and S. aureus.
The zones of inhibition increased and were comparable to those seen with established antibiotics like ciprofloxacin.
Compounds 6c, 6e, and 6i exhibited potent antifungal effects against C. albicans and A. niger, indicating strong therapeutic potential.
The promising results highlight the need for further research on the mechanism of action and in vivo effectiveness.

Bhardwaj et al. (2025) studied this question.

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