The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis

Dai‐Hong Xie; Jun Wang; Kai Sun; Zong-Yan Shi; Yazhe Wang; Yan Chang; Xiao‐Ying Yuan; Yanrong Liu; Hao Jiang; Qian Jiang; Xiao-Jun Huang; Ya‐Zhen Qin

doi:10.3390/biomedicines12102207

September 27, 2024BiomedicinesOpen Access

The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis

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Key Points

TIGIT expression on bone marrow NK cells exhibits functional and prognostic implications in core binding factor-acute myeloid leukemia, addressing an unresolved immune checkpoint role.
Evaluation examines newly identified immune checkpoint TIGIT on natural killer cells at diagnosis, detailing cellular profiles in core binding factor-acute myeloid leukemia.
Highlights the importance of bone marrow NK cells in core binding factor-acute myeloid leukemia, indicating that targeted immune checkpoint pathways warrant further clinical investigation.

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Implication

Analysis explores functional and prognostic impacts of TIGIT expression on bone marrow NK cells in core binding factor-acute myeloid leukemia at diagnosis, highlighting potential immune checkpoint...

Abstract

: The effect of the expression of the newly identified immune checkpoint, T cell immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) on NK cells in core binding factor-acute myeloid leukemia (CBF-AML) remains to be investigated.

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Xie et al. (2024) studied this question.

synapsesocial.com/papers/68e572c8b6db64358751321a https://doi.org/10.3390/biomedicines12102207

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The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis

Key Points

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Implication

Abstract

Discussion

Cite This Study

The Functional and Prognostic Impact of TIGIT Expression on Bone Marrow NK Cells in Core Binding Factor-Acute Myeloid Leukemia Patients at Diagnosis

Key Points

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Implication

Abstract

Discussion

Cite This Study

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