September 27, 2024CureusOpen Access

A Rare Case of Hemodialysis as an Extracorporeal Treatment for Severe Phenytoin Overdose

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Authors

RFRandy FelberNova Southeastern University VPVictoria R PragerNova Southeastern University DWDeena Werde

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Implication

Case report demonstrates effective elimination of toxic phenytoin via intermittent hemodialysis in an adult male, highlighting its utility for severe overdose.

Key Points

Intermittent hemodialysis accelerated drug clearance and resolved severe neurotoxicity in an adult suffering from massive extended-release phenytoin ingestion.
Serum phenytoin concentrations fell by 27% directly following a single hemodialysis session, resolving lethargy and speech impairment without rebound toxicity.
Supports hemodialysis as a viable extracorporeal treatment during life-threatening overdose, which may overcome saturation of hepatic metabolism despite albumin binding.

Cite This Study

Felber et al. (2024) studied this question.

synapsesocial.com/papers/68e572d6b6db6435875138cf https://doi.org/10.7759/cureus.70338

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Implication

Case report demonstrates effective elimination of toxic phenytoin via intermittent hemodialysis in an adult male, highlighting its utility for severe overdose.

A Rare Case of Hemodialysis as an Extracorporeal Treatment for Severe Phenytoin Overdose

Discussion

Member takes

Implication

Key Points

Cite This Study

A Rare Case of Hemodialysis as an Extracorporeal Treatment for Severe Phenytoin Overdose

Discussion

Member takes

Implication

Key Points

Cite This Study

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