Palladium‐Catalyzed Synthesis of Pyrrolo[1,2‐α]Pyrazines From N‐Phenacyl Pyrrole‐2‐Carbonitriles and Aryl Boronic Acids

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Herein, we have developed palladium‐trifluoroacetate‐catalyzed carbo‐palladation reaction of pyrrole‐2‐carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2‐α]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity‐oriented synthesis of pyrrolo[1,2‐α]pyrazines with broad substrate scope with respect to pyrrole‐2‐carbonitriles and aryl boronic acids.