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April 25, 2026Chemical Communications2 citationsOpen Access

Visible-Light Palladium Catalysis for Alkylated and Difluoroalkylated Pyrazolones

ADAnindya DasLKLennard KloeneSCSneha Chandra

Key Points

  • This research aims to explore a new method for synthesizing alkylated and difluoroalkylated pyrazolones using palladium catalysis. The study focuses on the application of a radical cascade technique in this synthesis.
  • Utilized photoinduced palladium-catalyzed protocol
  • Engaged unactivated alkyl and difluoroalkyl halides in the reaction
  • Conducted mechanistic studies to understand the synthesis process.
  • Successfully synthesized biologically relevant alkylated pyrazolones
  • Utilized a radical cascade mechanism for the synthesis
  • Highlighted the effectiveness of the new method for converting halides.

Abstract

We report a photoinduced palladium-catalyzed protocol for the synthesis of biologically relevant alkylated and difluoroalkylated pyrazolones via a radical cascade between N'-arylidene-N-acryloylphenylhydrazides and unactivated alkyl and difluoroalkyl halides. Mechanistic studies...

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Cite This Study

Das et al. (2026) studied this question.

synapsesocial.com/papers/69ec5a4488ba6daa22dabd15https://doi.org/10.1039/d6cc01889k
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Also Consider

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  1. 1Photoinduced C3 - Alkylation of Pyridines with Unactivated Alkyl Halides2026
  2. 2Visible-Light-Induced Alkoxypyridylation of Alkenes Using N-Alkoxypyridinium Salts as Bifunctional Reagents2024 · 19 citations
  3. 3Visible-Light-Promoted Intermolecular Annulation Toward Efficient Synthesis of Multisubstituted Pyrazoles2025
  4. 4Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones2025 · 9 citations
  5. 5Visible-Light Induced 1,2-Alkylpyridylation of Alkenes via Deacylation of Unactivated Ketones2026