Randomized trial demonstrates an effective alkylation method in pyridine derivatives, highlighting practical applications.
High Resolution Image Download MS PowerPoint Slide Herein, we disclose a photoinduced Pd-catalyzed protocol that enables a meta -alkylation of pyridines via dearomatized oxazine intermediates with unactivated alkyl halides as coupling partners. This method offers a practical gateway to rapidly and reliably incorporate primary, secondary, or even tertiary alkyl fragments at the C3 position of the pyridine core, including site-selective diversification of advanced azine derivatives.
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Du et al. (2026) studied this question.
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