September 26, 2024Frontiers in ImmunologyOpen Access

Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota

View Full Paper

Ask AI

Bookmark

Relief of ulcerative colitis symptoms occurred following administration of Huang Lian Jie Du decoction, which suppressed inflammatory macrophage activity in colonic tissues.
Doses of 2 and 4 g/kg of the formula lowered the disease activity index, while significantly decreasing the abundance of harmful Bacteroides and Odoribacter gut bacteria.
Assessment of dextran sulfate sodium induced colitis in mice was conducted over eight weeks, combining biochemical tissue profiling with 16S rRNA amplicon sequencing.
Highlights suppression of the csf1r src pathway and gut microbiota remodeling as therapeutic mechanisms—mouse model; further clinical translation and validation are required.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Preclinical study reveals that Huang Lian Jie Du decoction attenuates colitis in mice, suggesting therapeutic value through macrophage pathway inhibition and gut microbiota modulation.

Cite This Study

Su et al. (2024) studied this question.

synapsesocial.com/papers/68e57432b6db6435875144c8 https://doi.org/10.3389/fimmu.2024.1375781

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study reveals that Huang Lian Jie Du decoction attenuates colitis in mice, suggesting therapeutic value through macrophage pathway inhibition and gut microbiota modulation.

Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota

Key Points

Discussion

Implication

Cite This Study

Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider