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September 26, 2024Investigative Ophthalmology & Visual ScienceOpen Access

ER Stress and Mitochondrial Perturbations Regulate Cell Death in Retinal Detachment: Exploring the Role of HIF1α

Bhavneet Kaur Bruna Miglioranza Scavuzzi Meng-Ling Yang Jingyu Yao Lin Jia Steven F. Abcouwer David Zacks

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Abstract

Retinal detachment (RD) leads to photoreceptor (PR) hypoxia due to separation from the retinal pigment epithelium (RPE). Hypoxia stabilizes retinal hypoxia-inducible factor 1-alpha (HIF1α), crucial for PR survival during RD. This study explores the regulatory role of HIF1α in PR cell survival pathways during RD.

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Cite This Study

Kaur et al. (2024) studied this question.

synapsesocial.com/papers/68e5743bb6db643587514817 https://doi.org/10.1167/iovs.65.11.39

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