Non-immunogenic and reversible transgene expression using self-amplifying RNA

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicity2025 · 1 citations
2. 2Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity2025 · 2 citations
3. 3The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity2025
4. 4A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations2024 · 15 citations
5. 5Self‐Amplifying RNA‐Based Therapeutics: Advances, Challenges, and Future Perspectives2026