Tert-alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagents mediated by commercially available lanthanum chloride-lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates.
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Speed et al. (2024) studied this question.
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