Association of Triglyceride/Glucose Index with CRP and Ferritin Among Different Obesity Phenotypes of Non-diabetic Adult Bangladeshi

Introduction: Obesity is an alarming problem worldwide and it antedates insulin resistance (IR) as well as inflammation. Considering financial condition of Bangladesh, TyG index can be used for assessment of insulin resistance. As CRP and ferritin usually respond to any inflammatory condition, they are expected to be raised in obesity. Early detection of association between TyG index and inflammatory markers (CRP & ferritin) can help in prediction of severity of obesity induced health risks. Materials and Methods: A cross sectional analytical study was conducted in the Department of Biochemistry and Molecular Biology, (BSMMU) from March, 2022 to February, 2023. BMI was calculated, and individuals were classified into three obesity phenotypes: phenotype A (obese BMI, non-obese WC), phenotype B (non-obese BMI, obese WC), and phenotype C (obese BMI, obese WC). The Triglyceride-Glucose (TyG) index, serum ferritin, and CRP were assessed, and their correlations were analyzed across different obesity phenotypes. Results: TyG index was significantly higher in phenotype C compared to A & B. Plasma CRP and ferritin level were found to be highest in phenotype C in comparison to phenotype A and phenotype B. A moderate positive correlation was found between TyG index and serum ferritin but not with CRP in subjects belonging phenotype B. Very low positive correlation was found between CRP and ferritin in subjects of phenotype C. Conclusion: A significant association was shown between TyG index and serum ferritin among phenotype B. Plasma CRP showed no significant association with TyG index among different obesity phenotypes.