A simple strategy for the synthesis of a variety of tetrahydropyridines in good to excellent yields via a Cu(OTf)2 catalyzed quaternary ammonium salt mediated ring-opening of activated azetidines followed by cyclization with alkynes in a domino fashion (DROC) was described. The formation of the products has been explained by an SN2-type ring-opening of azetidines with alkynes.
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Shukla et al. (2024) studied this question.
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