We present the synthesis of 16 unprecedented sulfonyl fluoride functionalized 2-aminothiazoles in good to excellent yields. The transformation is simple to perform, tolerant of a wide range of functionality and regioselective for a single product. Additionally, we showcase the diversification of the novel 2-aminothiazoles through SuFEx click chemistry. Finally, we propose a plausible stepwise reaction mechanism.
No takes yet. Share an insight, caveat, or question.
Kop et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: