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September 25, 2024Open Access

Generation of a PARPi-sensitive homozygous BRCA1-methylated OVCAR8 cell line using targeted CRISPR gene editing

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Authors

KNKsenija NesicThe University of MelbourneSBSally BeardWalter and Eliza Hall Institute of Medical ResearchLXLijun XuQIMR Berghofer Medical Research Institute

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Nesic et al. (2024) studied this question.

synapsesocial.com/papers/68e5766bb6db643587516af8https://doi.org/10.1101/2024.09.23.614644
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1829 Understanding BRCA1-Methylation stability to improve PARP inhibitor responses in high-grade serous ovarian carcinomas2024
  2. 2584 Overcoming resistance to PARP inhibitor in ovarian cancer with BRCA2 reversion mutation2024
  3. 3Homozygous Loss of Recombination Repair Genes and Poly ADP-Ribose Polymerase Inhibitor Benefit for Patients With Ovarian Cancer2026
  4. 4Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk2025 · 5 citations
  5. 5BRCA-negative high-grade serous ovarian cancer with recurrent progression: A clinical case2025