Aromatic Abietane‐Type Diterpenoids from the Roots of Salvia prattii and their Protective Activity Against Alcoholic Liver Disease

Eighteen aromatic abietane‐type diterpenes, including three previously unreported compounds, Salkanoids A−C ( 1 – 3 ), were isolated from the roots of Salvia prattii . Their stuctures were extensively elucidated using 1D/2D NMR, high‐resolution electrospray ionization mass spectrometry (HRESIMS) data, and ECD calculation. Among these, compounds 1 , 6 and 7 belong to a class of diterpenes featuring a [5, 5]‐oxaspirolactones moiety, a rare structure isolated from the Salvia plants. All the isolates were assessed for their protective effects against alcoholic liver disease using ethanol‐induced AML‐12 cell lines. The findings revealed that compounds 2 , 5 , 8 and 15 demonstrated potential protective activity.