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September 24, 2024Open Access

Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study

Elaheh Salardini Ryan S. O’Dell Em Tchorz Nabeel Nabulsi Yiyun Huang Richard E. Carson Christopher H van Dyck Adam P. Mecca

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Abstract

The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer's disease (AD). Positron emission tomography (PET) studies of mGluR5 using [

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Salardini et al. (2024) studied this question.

synapsesocial.com/papers/68e578aeb6db643587518768 https://doi.org/10.1101/2024.09.21.614277

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