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March 19, 2024Molecular NeurobiologyOpen Access

Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease

Yanyan Kong Cinzia Maschio Xuefeng Shi Fang Xie Chuantao Zuo Uwe Konietzko Kuangyu Shi Axel Rominger Jianfei Xiao Qi Huang Roger M. Nitsch Yihui Guan Ruiqing Ni

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Abstract

Reactive astrocytes play an important role in the development of Alzheimer's disease (AD). Here, we aimed to investigate the temporospatial relationships among monoamine oxidase-B, tau and amyloid-β (Aβ), translocator protein, and glucose metabolism by using multitracer imaging in AD transgenic mouse models. Positron emission tomography (PET) imaging with [

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Cite This Study

Kong et al. (2024) studied this question.

synapsesocial.com/papers/68e734edb6db6435876ae40d https://doi.org/10.1007/s12035-024-04106-7

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Astrocyte reactivity across the AD continuum measured by [18F]SMBT-1 and its relationship with the Aβ burdenHuman Clinical Trial · 2026 · 2 citations
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