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September 23, 2024JAMA Neurology

Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures

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Authors

SZSahar F. ZafarHarvard UniversityASAdithya SivarajuUniversity of North Carolina at CharlotteCRClio RubiñosUniversity of North Carolina at Chapel Hill

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Implication

Multicenter cohort study finds antiseizure medications do not improve functional recovery in acute symptomatic seizures, highlighting the need for clinical trials.

Key Points

  • Inpatient antiseizure medications were not associated with improved functional outcomes at discharge or at three months following acute symptomatic seizures.
  • Multicenter cohort study of 1172 adults undergoing continuous electroencephalography found that 45% received treatment and 31% had discharge antiseizure medications.
  • Highlights that epileptiform abnormalities drive routine prescribing without clear functional benefit, calling for randomized trials to determine optimal duration.

Cite This Study

Zafar et al. (2024) studied this question.

synapsesocial.com/papers/68e579c7b6db6435875191f1https://doi.org/10.1001/jamaneurol.2024.3189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Seizure burden in subarachnoid hemorrhage associated with functional and cognitive outcome2015 · 217 citations
  2. 2Characteristics and Attendance of Patients Eligible for the PASS Clinic2024 · 8 citations
  3. 3Effectiveness of antiseizure medications therapy in preventing seizures in brain injury patients: A network meta-analysis2022 · 22 citations
  4. 4Prophylactic Seizure Medication and Health-Related Quality of Life After Intracerebral Hemorrhage2018 · 57 citations
  5. 5The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies2007 · 20,916 citations