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September 23, 2024JACS AuOpen Access

2,2-Difluoro Derivatives of Fucose Can Inhibit Cell Surface Fucosylation without Causing Slow Transfer to Acceptors

Yanyan Liu Igor R. Sweet Geert‐Jan Boons

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Abstract

Fucosyl transferases (FUTs) are enzymes that transfer fucose (Fuc) from GDP-Fuc to acceptor substrates, resulting in fucosylated glycoconjugates that are involved in myriad physiological and disease processes. Previously, it has been shown that per-

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Liu et al. (2024) studied this question.

synapsesocial.com/papers/68e579d7b6db643587519897 https://doi.org/10.1021/jacsau.4c00681

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