In rare cases, testicular cancer can metastasize to the inferior vena cava (IVC) through a tumor thrombus, significantly worsening the prognosis. This case report describes the management and the outcome of a rare presentation of testicular cancer. A 38-year-old male presented with a testicular mass and was found to have a mixed germ cell tumor with predominantly yolk sac components. Imaging after the initial orchiectomy revealed an IVC tumor thrombus extending from the left renal vein, as well as retroperitoneal and pulmonary metastases. The patient was urgently started on anticoagulation and underwent three cycles of BEP chemotherapy (bleomycin, etoposide, and cisplatin), which led to complete metabolic and radiographic regression of the metastatic disease.
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Khushaym et al. (2024) studied this question.
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