September 21, 2024Cancer Epidemiology Biomarkers & Prevention

Abstract C117: Integrative multi-omics profiling in patients of African descent diagnosed with prostate cancer reveals distinct tumor-promoting immunosuppressive niches at a single-cell level and spatial resolution

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Authors

IEIsra ElhussinJohns Hopkins University EBEzra BarabanJohns Hopkins University AKAshley KiemenJohns Hopkins University

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Implication

Observational multi-omics analysis reveals distinct immunosuppressive niches in prostate cancer patients of African descent, highlighting ancestry-driven mechanisms of disease aggressiveness.

Key Points

Patients of African descent exhibit suppressive myeloid cells and open chromatin accessibility with STAT motif enrichment within the prostate tumor microenvironment.
Across 447 patients, whole exome sequencing and whole transcriptome sequencing revealed STAT motif enrichment with a p-value below 0.0001 in African American tumors.
Highlights from multi-plex profiling and spatial resolution mapping demonstrate that ancestry-linked immune suppression may drive clinical disparities in aggressive prostate cancer.

Cite This Study

Elhussin et al. (2024) studied this question.

synapsesocial.com/papers/68e57c1db6db64358751b4ef https://doi.org/10.1158/1538-7755.disp24-c117

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Implication

Observational multi-omics analysis reveals distinct immunosuppressive niches in prostate cancer patients of African descent, highlighting ancestry-driven mechanisms of disease aggressiveness.

Abstract C117: Integrative multi-omics profiling in patients of African descent diagnosed with prostate cancer reveals distinct tumor-promoting immunosuppressive niches at a single-cell level and spatial resolution

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract C117: Integrative multi-omics profiling in patients of African descent diagnosed with prostate cancer reveals distinct tumor-promoting immunosuppressive niches at a single-cell level and spatial resolution

Discussion

Member takes

Implication

Key Points

Cite This Study

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