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September 20, 2024ACS Nano

Paclitaxel Prodrug Enables Glutathione Depletion to Boost Cancer Treatment

Biyou Zhang Shiyu Zhou Shaojin Lu Xiujuan Xiang Xiumin Yao Wentao Lei Qing Pei Zhigang Xie Xuesi Chen

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Abstract

Herein, we constructed a paclitaxel (PTX) prodrug (PA) by conjugating PTX with acrylic acid as a cysteine-depleting agent. The as-synthesized PA can assemble with diacylphosphatidylethanolamine-PEG

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e57c24b6db64358751b850 https://doi.org/10.1021/acsnano.4c06399

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