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September 20, 2024Critical CareOpen Access

Infusion of sodium DL-3-ß-hydroxybutyrate decreases cerebral injury biomarkers after resuscitation in experimental cardiac arrest

Filippo Annoni Fuhong Su Lorenzo Peluso Ilaria Lisi Enrico Caruso Francesca Pischiutta Elisa Gouvêa Bogossian Bruno Garcia Hassane Njimi Jean‐Louis Vincent Nicolas Gaspard Lorenzo Ferlini Jacques Créteur Elisa R. Zanier Fabio Silvio Taccone

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Abstract

Cerebral complications after cardiac arrest (CA) remain a major problem worldwide. The aim was to test the effects of sodium-ß-hydroxybutyrate (SBHB) infusion on brain injury in a clinically relevant swine model of CA.

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Cite This Study

Annoni et al. (2024) studied this question.

synapsesocial.com/papers/68e57d2fb6db64358751be19 https://doi.org/10.1186/s13054-024-05106-8

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hypertonic lactate infusion reduces vasopressor requirement and biomarkers of brain and cardiac injury after experimental cardiac arrestpreclinical · 2023
2β-hydroxybutyrate alleviates neurological deficits by restoring glymphatic and inflammation after subarachnoid hemorrhage in mice2024 · 27 citations
3Hemodynamic effects of treatment with the ketone body 3-hydroxybutyrate in cardiogenic shock - a randomized, controlled, assessor-blinded porcine trial2024
4Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model2024 · 2 citations
5Sodium octanoate attenuates early post-resuscitation renal injury after hemorrhagic-induced cardiac arrest in a porcine modelOriginal Research · 2026

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