Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia

Verónica Alonso-Pérez; Klaudia Galant; Fabien Boudia; Elie Robert; Zakia Aid; Laurent Renou; Vilma Barroca; Saryiami Devanand; Loélia Babin; Virginie Rouiller‐Fabre; Delphine Moison; Didier Busso; Guillaume Piton; Christophe Metereau; Nasséra Abermil; Paola Ballerini; Pierre Hirsch; Rima Haddad; Jéléna Martinovic; Arnaud Petit; Hélène Lapillonne; Erika Brunet; Thomas Mercher; Françoise Pflumio

doi:10.1186/s12943-024-02110-y

Abstract

Several fusion oncogenes showing a higher incidence in pediatric acute myeloid leukemia (AML) are associated with heterogeneous megakaryoblastic and other myeloid features. Here we addressed how developmental mechanisms influence human leukemogenesis by ETO2::GLIS2, associated with dismal prognosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Alonso-Pérez et al. (2024) studied this question.

synapsesocial.com/papers/68e57d34b6db64358751c29b https://doi.org/10.1186/s12943-024-02110-y

View Full Paper

Ask AI

Bookmark

Share

Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia

Abstract

Discussion

Cite This Study

Developmental interplay between transcriptional alterations and a targetable cytokine signaling dependency in pediatric ETO2::GLIS2 leukemia

Abstract

Discussion

Cite This Study

Keep reading

Keep reading