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September 19, 2024Frontiers in EndocrinologyOpen Access

A comprehensive prediction model for central lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis: BRAF may not be a valuable predictor

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Authors

YCYanwei ChenSZShuangshuang ZhaoZZZheng Zhang

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Overview

Retrospective study uncovers predictors of central lymph node metastasis in papillary thyroid carcinoma with Hashimoto thyroiditis, suggesting BRAF mutation status lacks predictive utility.

Key Points

  • Central lymph node metastasis correlates with male sex and tumor size in papillary thyroid carcinoma with Hashimoto thyroiditis, whereas BRAF mutation status does not predict spread.
  • An area under the curve of 0.82 validated the prediction model, which attained 77.5% accuracy for detecting central lymph node metastasis in papillary thyroid carcinoma.
  • Retrospective multivariate logistic regression analysis establishes a clinical nomogram that may guide surgical decisions without requiring routine BRAF mutation testing.

Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e57fb3b6db64358751d798https://doi.org/10.3389/fendo.2024.1429382
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