Severe Sarcoidosis Demonstrates Heterogenous Immune Dysregulation Across Different Peripheral Immune Cell Types: A Single-Center Single Cell Multi-omic Analysis

Sarcoidosis provides unique management challenges due to variable presentation and disease course. In this single-center analysis, we assess transcriptomic and epigenomic differentiators between severe and mild cases of sarcoidosis using peripheral blood. We showcase differences across multiple cell types that highlight decreased immunoregulation and increased inflammation in severe sarcoidosis. We provide an overall framework for the interactions between immune cells in severe sarcoidosis as a basis for future therapeutic research.