Figure 3 from The Proteogenomics of Prostate Cancer Radioresistance

Fractionation-dependent protein profiles in radioresistant cells. A, The difference in relationships of consensus-module eigengenes and cellular fractions between CF- and HF-resistant cells. The colors represent the difference in correlations between consensus module eigengenes and a specific subcellular fraction of HF-resistant cells compared to CF: Blue, a higher correlation in CF-resistant cells; Red, a higher correlation in HF-resistant cells. At the top, each color represents a module, which is a detected group of positively correlated genes that are highly interconnected. B, Gene ontology enrichment of module genes for biological processes. The top two enrichments for each module are presented. C, Differences in protein abundances of driver, across different subcellular fractions and in whole cell lysates. Main, protein Cohen’s d effect sizes of significant proteins across cell fractions. Only significant changes at the level of FDR ≤ 0.025 were plotted. The dot color is the directionality: magenta and green represent upregulation and downregulation, respectively, toward CF- or HF-resistant cells. Right, the consensus modules that each gene was assigned to. For all figures, three replicates were used for CF- and HF- resistant cells. For the parental cells, at least two replicates were used.