September 18, 2024Alzheimer s & DementiaOpen Access

The plasma miRNAome in ADNI: Signatures to aid the detection of at‐risk individuals

View Full Paper

Ask AI

Bookmark

Authors

DKD. KrügerGerman Center for Neurodegenerative Diseases TCTonatiuh Peña CentenoGerman Center for Neurodegenerative Diseases SLShiwei LiuIndiana University

Discussion

Member takes

Implication

Cohort study reveals plasma microRNA profiles predict Alzheimer disease progression in mild cognitive impairment, highlighting opportunities to reduce invasive diagnostic testing.

Key Points

Plasma microRNA signatures correlate with Alzheimer's disease diagnoses, and these circulating markers help predict progression from mild cognitive impairment.
Profiling plasma samples from 847 participants identified microRNA biomarkers that increase the diagnostic accuracy of conventional neuropsychological testing.
Small RNA sequencing of participant plasma was conducted to evaluate the circulating microRNAome, targeting molecules regulating proteostasis across the cohort.
May enable reduced reliance on costly and invasive testing across aging populations, establishing plasma microRNAome profiling for early risk stratification.

Cite This Study

Krüger et al. (2024) studied this question.

synapsesocial.com/papers/68e580d4b6db64358751e8b8 https://doi.org/10.1002/alz.14157

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals plasma microRNA profiles predict Alzheimer disease progression in mild cognitive impairment, highlighting opportunities to reduce invasive diagnostic testing.

The plasma miRNAome in ADNI: Signatures to aid the detection of at‐risk individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

The plasma miRNAome in ADNI: Signatures to aid the detection of at‐risk individuals

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider