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September 18, 2024Journal of Medicinal Chemistry

Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L

Weilong Deng Xiao Hu Xiaoman Tian Yuanyuan Zhang Weijuan Shang Leike Zhang Luqing Shang

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Abstract

Cathepsin L (CatL) is a promising antiviral drug target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an important protease for cleaving the SARS-CoV-2 spike protein and enhancing viral entry to cells. We identified a tripeptide aldehyde candidate,

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Deng et al. (2024) studied this question.

synapsesocial.com/papers/68e580ddb6db64358751ecd4 https://doi.org/10.1021/acs.jmedchem.4c00656

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