September 16, 2024Journal of Clinical InvestigationOpen Access

HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes

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Preproinsulin-reactive T cell receptors cross-recognize bacterial peptides under HLA class I restriction, triggering destruction of insulin-producing pancreatic beta cells.
In 7 of 8 healthy donors, a bacterial Klebsiella epitope primed cross-reactive T cell receptor clones that killed target cells presenting self antigens.
Combinatorial peptide library screening and crystal seeding reveal molecular mimicry between microbes and beta cells, supporting a pathogen-triggered onset of type 1 diabetes.

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Implication

Experimental study demonstrates cross-recognition of bacterial and preproinsulin peptides by CD8+ T cells in HLA A*24:02 donors, highlighting molecular mimicry in type 1 diabetes.

Cite This Study

Dolton et al. (2024) studied this question.

synapsesocial.com/papers/68e58475b6db643587521520 https://doi.org/10.1172/jci164535

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Implication

Experimental study demonstrates cross-recognition of bacterial and preproinsulin peptides by CD8+ T cells in HLA A*24:02 donors, highlighting molecular mimicry in type 1 diabetes.

HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes

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Discussion

Implication

Cite This Study

HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes

Key Points

Discussion

Implication

Cite This Study

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