Comprehensive Summary We report a palladium‐catalyzed asymmetric [4+4] cycloaddition reaction between 2‐alkylidenetrimethylene carbonate and electron‐deficient indole‐2,3‐quinodimethanes ( IQDMs ). This reaction features exclusive regioselectivity, high yield (up to 98%), excellent enantioselectivity (up to 95% ee), and easy scale‐up without any loss of efficiency, making it valuable for the synthesis of indole‐fused eight‐membered oxa‐rings.
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Lu et al. (2024) studied this question.
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