Supplemental Figure 1 from USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis

Schematic Model. Constitutive activation of the RAS/RAS/MEK/ERK axis phosphorylates the deubiquitinase USP10 at serine 236, and this phosphorylation induces the dissociation of USP10 from ZEB1 resulting in stabilization of ZEB1.