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October 7, 2025JPGN ReportsOpen Access

A case of autoimmune hepatitis in a patient with inflammatory bowel disease and significant lymphadenopathy in the porta hepatis

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Authors

BMBenjamin MalametWashington University in St. LouisSJShannon JoergerWashington University in St. LouisKCKaren CaudillWashington University in St. Louis

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Implication

Case presentation highlights diagnostic challenges of autoimmune hepatitis in inflammatory bowel disease, suggesting complexities in identifying liver pathology.

Key Points

  • Diagnosis of autoimmune hepatitis confirmed via liver biopsy after excluding other causes of elevated transaminases.
  • Patient exhibited elevated transaminases and hypergammaglobulinemia but lacked typical AIH autoantibodies.
  • Hepatic ultrasound revealed lymphadenopathy, raising concerns for infection or malignancy.
  • Patient's history of inflammatory bowel disease treatment with vedolizumab and prior azathioprine contributes to diagnostic complexities.

Cite This Study

Malamet et al. (2025) studied this question.

synapsesocial.com/papers/68e585d0b1e78cc4e5f46495https://doi.org/10.1002/jpr3.70093
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long‐term safety of vedolizumab for inflammatory bowel disease2020 · 199 citations
  2. 2Hepatic Issues and Complications Associated With Inflammatory Bowel Disease2016 · 40 citations
  3. 3Diagnosis and Management of Pediatric Autoimmune Liver Disease2017 · 355 citations
  4. 4Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group2022 · 159 citations