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September 16, 2024

Supplementary Figure S3 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

Kathryn Gunn Matti Myllykoski John Z. Cao Manna Ahmed Bofu Huang Betty Rouaisnel Bill H. Diplas Michael M. Levitt Ryan Looper John G. Doench Keith L. Ligon Harley I. Kornblum Samuel K. McBrayer Hai Yan Cihangir Duy Lucy A. Godley Peppi Koivunen Julie-Aurore Losman

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Abstract

Trimethyl-H3K4 is not enriched upon knock-down of TET2 in TF-1 cells.

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Gunn et al. (2024) studied this question.

synapsesocial.com/papers/68e586c1b6db6435875233f7 https://doi.org/10.1158/2159-8290.27025181.v1

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
2Supplementary Figure S1 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
3Supplementary Figure S1 from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
4Supplementary Figure S9: from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024
5Supplementary Figure S9: from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers2024