Data from Effectiveness and Cost of an Enhanced Mailed Fecal Test Outreach Colorectal Cancer Screening Program: Findings from the PROMPT Stepped-Wedge Trial

Abstract Background: Mailed fecal immunochemical test (FIT) outreach can improve colorectal cancer screening rates, yet little is known about how to optimize these programs for effectiveness and cost. Methods: PROMPT was a pragmatic, stepped-wedge, cluster-randomized effectiveness trial of mailed FIT outreach. Participants in the standard condition were mailed a FIT and received live telephone reminders to return it. Participants in the enhanced condition also received a tailored advance notification (text message or live phone call) and two automated phone call reminders. The primary outcome was six-month FIT completion; secondary outcomes were any CRC screening completion at six months, implementation, and program costs. Results: The study included 27,585 participants (80% ages 50-64, 82% Latino; 68% preferred Spanish). A higher proportion of enhanced participants completed FIT at six months than standard participants, both in intention-to-treat (+2.8%, 95% CI [0.4%, 5.2%]) and per-protocol (limited to individuals who were reached; +16.9%, 95% CI [12.3%, 20.3%]) analyses. Text messages and automated calls were successfully delivered to 91- 100% of participants. The per-patient cost for standard mailed FIT was $10.84. The enhanced program’s text message plus automated call reminder cost an additional $0.66 live phone calls plus an automated call reminder cost an additional $10.82 per patient. Conclusions: Adding advance notifications and automated calls to a standard mailed FIT program boosted six-month FIT completion rates at a small additional per-patient cost. Impact: Enhancements to mailed FIT outreach can improve colorectal cancer screening participation. Future research might test the addition of educational video messaging for screening-naïve adults.