In vitro analysis demonstrates MEK inhibition amplifies STING-induced cytokine transcription across PDAC cell lines, suggesting enhanced antitumor innate immune activation.
Supplementary Fig. 3 MEK inhibition amplifies STING-induced transcription of IFNB1, IL-6, and TNFA in multiple PDAC cell lines.
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Ghukasyan et al. (2024) studied this question.
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