Successful Treatment of Lipschütz Ulcer with a JAK Inhibitor, Upadacitinib

Lipschütz ulcer (LU), is a rare non-venereal diagnosis of exclusion. Typically affecting sexually inactive, young women, LU presents with acute pain and edema along with necrotic ulcerations on the vulva, labia minora, or lower vaginal region. The pathogenesis of LU remain unknown. Published cases suggest that LU may heal spontaneously or with supportive and symptomatic treatment focused on pain relief and inflammation reduction using oral or topical steroids. Here, we present a case of persistent LU that required continuous treatment with a janus kinase (JAK) inhibitor, upadacitinib.