Investigation reveals NuRD chromatin remodeling repairs exogenous DNA double-strand breaks in Caenorhabditis elegans germ cells, highlighting chromatin regulation during genome defense.
Organisms rely on coordinated networks of DNA repair pathways to protect genomes against toxic double-strand breaks (DSBs), particularly in germ cells. All repair mechanisms must successfully negotiate the local chromatin environment in order to access DNA. For example, nucleosomes can be repositioned by the highly conserved Nucleosome Remodeling and Deacetylase (NuRD) complex. In
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Ananthaswamy et al. (2024) studied this question.
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