Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

Abhishek Singh; Fernaldo Richtia Winnerdy; Constanza Avendaño Avila; Claude Noguès; Anh Tuân Phan; Brahim Heddi

doi:10.1021/jacs.4c05713

September 14, 2024Journal of the American Chemical Society

Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

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Key Points

Interlocking occurs between two intramolecular G-quadruplexes, where a vacant guanine site within the G-tetrad core enables stable noncanonical pairing.
Biochemical evaluation identifies a G-triad connection that bridges the vacant site, facilitating stable associations across nucleic acids sequences.
Supports the design of programmable nanostructures and may enable guided G-wire assembly, expanding synthetic applications of noncanonical nucleic acids.

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Implication

Structural evaluation reveals interlocking of two intramolecular G-quadruplexes in nucleic acids, suggesting new architectural principles for G-wire assembly.

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Cite This Study

Singh et al. (2024) studied this question.

synapsesocial.com/papers/68e5891fb6db643587524e6e https://doi.org/10.1021/jacs.4c05713

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Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

Key Points

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Implication

Discussion

Cite This Study

Interlocking G-Quadruplexes Using a G-Triad•G Connection: Implications for G-Wire Assembly

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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