Alternative Splicing Dysregulation Across Tissue Type and Therapeutic Treatment Approaches in the HSALR Mouse Model of Myotonic Dystrophy Type 1

This is the authors' abstract. We don't add key points for this paper.

Myotonic dystrophy type 1 (DM1), the leading cause of adult-onset muscular dystrophy, is caused by a CTG repeat expansion. Expression of the repeat causes widespread alternative splicing (AS) defects and downstream pathogenesis, including significant skeletal muscle impacts. The