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September 13, 2024AntibioticsOpen Access

Characterization of Two Novel Endolysins from Bacteriophage PEF1 and Evaluation of Their Combined Effects on the Control of Enterococcus faecalis Planktonic and Biofilm Cells

Chen Wang Junxin Zhao Yunzhi Lin Su Zar Chi Lwin Mohamed El‐Telbany Yoshimitsu Masuda Ken‐ichi Honjoh Takahisa Miyamoto

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Abstract

Endolysin, a bacteriophage-derived lytic enzyme, has emerged as a promising alternative antimicrobial agent against rising multidrug-resistant bacterial infections. Two novel endolysins LysPEF1-1 and LysPEF1-2 derived from

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Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e58a50b6db643587525d55 https://doi.org/10.3390/antibiotics13090884

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Endolysin LysPEF52H from <i>Enterococcus faecalis</i> phage PEF-SWUN52H: a potential antibacterial agentOriginal Research · 2026
2Investigating Novel<i>Streptomyces</i>Bacteriophage Endolysins as Potential Antimicrobial Agents2024 · 1 citations
3A Novel Enterococcus Phage Endolysin Lys22 with a Wide Host Range Against Mixed Biofilm of Enterococcus faecalis, Staphylococcus aureus, and Acinetobacter baumannii2025 · 3 citations
4Characterization and phage-antibiotic synergy of bacteriophages PES-1 and PES-2 against porcine enterotoxigenic Escherichia coliOriginal Research · 2026 · 1 citations
5Engineered endolysin of Klebsiella pneumoniae phage is a potent and broad-spectrum bactericidal agent against “ESKAPEE” pathogens2024 · 15 citations

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Innovative Utilization of Endolysins for Future Battle Against Superbugs2026
Endolysins: a new antimicrobial agent against antimicrobial resistance. Strategies and opportunities in overcoming the challenges of endolysins against Gram-negative bacteria2024
Bacteriophage Endolysin: Isolation, Cloning, and Antibacterial Activity2024

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